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How to protect yourself from the effects of a carriage, acute or chronic Mycoplasma in pregnancy

In developed countries in the last decade, intrauterine infection of the fetus occurs more frequently than bacterial agents, and persistent intracellular (slow) infection. On the first row of statistics are Mycoplasma.

A predisposition to infection due to physiological immunosuppression in pregnant women. The decrease in the level of resistance leads to the development of diseases of the urogenital tract, infection of the fetus, the formation of congenital anomalies, premature birth, miscarriage.

What are Mycoplasma threaten the future mother

From the class Mollicutes (mollicute) normal pregnancy and a successful birth, according to scientists, is threatened:

  • recognized by the pathogen Mycoplasma genitalium;
  • opportunistic Ureaplasma urealyticum, Mycoplasma hominis.

They lack cell walls, instead of which has a three-layer cytoplasmic membrane. This feature leads to the non-viability of prokaryotes outside the host cell but provides high penetrating ability and resistance to immunity within the body.

The pathogenesis of urogenital mycoplasmosis in pregnant women

Microorganisms penetrate into the cell due to adesina. They are protected from the immune response, both humoral and cellular, that firmly attached to membranes and interact with cell. The pathological factor is the allocation of mycoplasmas in the host organism of enzymes and toxins. In the process of life is a parasite it feeds on cells, disrupts protein synthesis and metabolism, exchange of biological signals, makes "junk" genetic information.

For healthy people Mycoplasma become dangerous in cases of concentrations greater than 104 CFU per 1 ml discharge in the lesion. In conditions of low immunity, pregnant women can respond to fewer germs.

Colonization of the urogenital organs of the female Mycoplasma could happen:

  1. Before pregnancy, then she is either a carrier of pathogens or suffer from chronic diseases.
  2. In the early stages of pregnancy.
  3. In the last trimester.

In the latter two cases, Mycoplasma infections will develop acute.

The infection is transmitted by:

  • sexual way;
  • prenatal;
  • neonatal.
Пути заражения плода микоплазмами

Comprehensive treatment includes immunomodulators, multiprobiotics (1-3 months), homeopathic remedies, multivitamins, medications.

Timely and complete treatment of mycoplasmosis in pregnant women reduces the frequency of complications in childbirth, the probability of birth of sick children.

Sources:

  1. Borisenko K. K., Taskin I. A.,Kisina V. I. On the significance of colonization of the urinary organs M. hominis and U. class // STIs. – 1999. – No. 3. – S. 28-32.
  2. Kagan, G. Ya., Rakovskaya I. V. Mycoplasma infection in tissue cultures. – M., 1968.
  3. Maltseva L. I., Andrushko I. A. Pathogenetic role of disorders of the hemostatic system in the urogenital Mycoplasma infection in women // Arch. patol. – 1995. – No. 5. – S. 118-122.
  4. Nemchenko O. I., Uvarov E. V. Urogenital mycoplasmosis (literature review) // Consilium Medicum. – 2007. – No. 1. – P. 45-51.
  5. Prilepskaya V. Kissin, V., Sokolovsky A., et al. To the question about the role of mycoplasmas in urogenital disease // Gastroenterology. – 2007. No. 9. – S. 31-38.
  6. Hudson M. M. T. Ureaplasma urealyticum // STD. – 1998. – No. 1. – S. 10-13.
  7. Chernova O. A., Chernov V. M. Genetic variability of Mycoplasma during their interaction with host organisms vertical migration and restructuring in the genes of surface antigenic determinants), Dokl. Russian Academy of Sciences. – 1999. – No. 366. – Pp. 125-127.
  8. Schlegel G. General Microbiology. – M., 1987.
  9. Baseman, J. B., Cagle, M., Korte J. E. et al. Diagnostic assessment of Mycoplasma genitalium in culture-positive women // J. Clin. Microbiol. – 2004. – Vol. 42. – P. 203-211.
  10. Gambini d, Decleva I., Lupica l, Ghislanzoni m, Cusini m, Alessi E. Mycoplasma genitalium in males with nongonococcal urethritis: prevalence and clinical efficacy of eradication // Sex. Transmission. Dis. – 2000. – Vol. 27. – P. 226-229.
  11. Cassel G. H., K. B. Waites, D. T. Crouse et al. Isolation of Mycoplasma hominis and Ureaplasma urealyticum from amniotic fluid at 16-20 weeks gestation: potential effects on outcome of pregnancy // Sex. Transmission. Dis. – 1983. – Vol. 10. – P. 294-302.
  12. Cook R., Hutchison S., Ostergaard L. et al. Systematic review: noninvasive testing for Chlamydia trachomatis and Neisseria gonorrhoeae // Ann. Intern. Med. – 2005. – Vol. 142. – P. 914-925.
  13. N. Dupin, G. Bijaoui, M. Schwarzinger et. al. Detection and quantification of Mycoplasma genitalium in male patients with urethritis // Clin. Infect. Dis. – 2003. – Vol. 37. – P. 602-605.
  14. Falk L., Fredlund H., Jensen J. S. Tetracycline treatment does not eradicate Mycoplasma genitalium // Sex. Transmission. Infect. – 2003. – Vol. 79. – P. 318-319.
  15. Foy H. et al. Prevalence of Mycoplasma hominis and Ureaplasma urealiticum (T strains) in urine in adolescents // J. Clin. Microbiol. – 1975. – Vol. 2. – P. 226.
  16. Hamasuna R., Osada Y., Jensen J. S. Antibiotic susceptibility testing of Mycoplasma genitalium by TaqMan 5’ nucleases real-time PCR // Antimicrob. Agents Chemother. – 2005. – Vol. 49. – P. 4993-4998.
  17. Hannan P. C. Comparative susceptibilities of various AIDS-associated and human urogenital tract mycoplasmas and strains of Mycoplasma pneumoniae to 10 classes of antimicrobial agent in vitro // J. Med. Microbiol. – 1998. – P. 1115-1122.
  18. Horner P. J., C. B. Gilroy, B. J. Thomas, Naidoo R. J., Taylor-Robinson D. Association of Mycoplasma genitalium with acute non-gonococcal urethritis // Lancet. – 1993. – Vol. 342. – P. 582-585.
  19. Iwasaka, T., Wada T., Kidera y, Sugimori H. Hormonal status and mycoplasma colonization in the female genital tract // Obstet. Gynecol. – 1986. – Vol. 68(2). – P. 263-266.
  20. Jensen J. S., Hansen T. H., Lind K. Isolation of Mycoplasma genitalium strains from the male urethra // J. Clin. Microbiol. – 1996. – Vol. 34. – P. 286-291.
  21. Jensen, J. S., R. Orsum, B. Dohn, S. Uldum, A. M. Worm, and K. Lind Mycoplasma genitalium: a cause of male urethritis? // Genitourin. Med. – 1993. – Vol. 69. – P. 265-269.
  22. Jensen J. S. Mycoplasma genitalium – the aetiologic agent of urethritis and other sexually transmitted diseases // J. Eur. Acad. Dermatol. Venereol. – 2004. – Vol. 18. – P. 1-11.
  23. Jensen J. S., Bjornelius E., Dohn B. et al. Use of TaqMan 5’ nucleases real-time PCR for quantitative detection of Mycoplasma genitalium DNA in males with and without urethritis who were attendees at a sexually transmitted disease clinic // J. Clin. Microbiol. – 2004. – Vol. 42. – P. 683-692.
  24. Jensen J. S., Bjornelius E., Dohn B. et al. Comparison of first void urine and urogenital swab specimens for detection ofMycoplasma genitalium and Chlamydia trachomatis by polymerase chain reaction in patients attending a sexually transmitted disease clinic // Sex. Transmission. Dis. – 2004. – Vol. 31. – P. 499-507.
  25. Jensen J. S. Mycoplasma genitalium infections. Diagnosis, clinical aspects, and pathogenesis // Kopenhagen. – 2005.
  26. G. Johannisson, Y. Enstrom, Lowhagen, G. Occurrence and treatment of Mycoplasma genitalium in patients visiting STD clinics in Sweden // Int. J. STD AIDS. – 2000. – Vol. 11. – P. 324-326.
  27. Lee Y.-H. et al. Reevalution of the role of T-mycorlasmas in nongonococcal urethritis // J. Amer. Vener. Dis. Assoc. – 1976. – Vol. 3. – P. 25.
  28. Lind, K., Lindhardt, B. O., Schutten B. H., Blom J., Christiansen C. Serological cross-reactions between Mycoplasma genitalium and Mycoplasma pneumoniae // J. Clin. Microbiol. – 1984. – Vol. 20. – P. 1036-1043.
  29. S. I. Maeda, M. Tamaki, K. Kojima et al. Assotiation of Mycoplasma genitalium persistence in the urethra with recurrence of nongonococcal urethritis // Sex. Transmission. Dis. – 2001. – Vol. 28. – P. 472-476.
  30. McCormack W. M., Almeida P. C., Bailey P. E., Grady E. M., Lee Y. H. Sexual activity and vaginal colonization with genital mycoplasmas // JAMA. – 1972. – Vol. 221(12). – P. 1375-1377.
  31. McCormack W. M. Clinical spectrum of infection with Neisseria gonorrhoeae // Sex. Transmission. Dis. – 1981. – Vol. 8(4). – P. 305-307.
  32. Miettinen A. Mycoplasma hominis in patients with pelvic inflammatory disease // Isr. J. Med. Sci. – 1987. – Vol. 23(6). – P. 713-716.
  33. Naessens A. Les infections a Ureaplasma urealyticum. Microbiologic // Acta Urol. Belg at. – 1993. – Vol. 61(1-2). – P. 153-156.
  34. Robertson B. D., Meyer T. F. Genetic variation in pathogenic bacteria // Trends Genet. – 1992. – Vol. 8. – P. 422-427.
  35. Shafer M. A., Sweet R. L., Ohm-Smith M. J., Shalwitz J., Beck A., Schachter J. Microbiology of the lower genital tract in postmenarchal adolescent girls: difference by sexual activity, contraception and presence of non-specific vaginitis // J. Pediatr. – 1985. – Vol. 107(6). – P. 974-981.
  36. Tait J., Peddie B. A., Bailey R. R. et al. Urethral syndrome (abacterial cystitis) – search for a pathogen // Brit. J. Urol. – 1985. – Vol. 57. – P. 552-556.
  37. Taylor-Robinson d, Furr P. M. Genital mycoplasma infections // Wien Klin Wochenschr. – 1997. – Vol. 109(14-15). – P. 578-583.
  38. Uuskula A., Kohl, P. K. Genital mycoplasmas, including Mycoplasma genitalium, as sexually transmitted agents // Int. J. STD AIDS. – 2002. – Vol. 13(2). – P. 79-85.
  39. Yoshida T., Deguchi T., Ito M., Maeda S., Tamaki M., Ishiko H. Quantitative detection of Mycoplasma genitalium from first-pass urine of men with urethritis and asymptomatic men by real-time PCR // J. Clin. Microbiol. – 2002. – Vol. 40. – P. 1451-1455.