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Features of diagnostics and actions of cytomegalovirus DNA on the body

The causative agent of the disease hominis Cytomegalovirus (CMV) related to opportunistic infections, are not able to exist outside of the human body for more than 20 minutes. In addition, the virus instantly killed at temperatures above 56 degrees. Quaternary and tertiary structure of a protein dies and the DNA is no longer able to reproduce the information.

Transmitted by aerosol and contact. Often through sexual contact, as transplacental route, in the composition of body fluids in the blood transfusions. Doctors do not exclude completely and contact-household transmission of CMV.

Than the virus is dangerous for fetal development

Maximum risk CMV poses to a developing fetus. Especially in the first trimester of pregnancy when DNA strands in the cells of the fetus synthesize complementary chains of proteins and there is a bookmark of organs, the differentiation of tissues. The virus integrates into the DNA, breaking the correct order of the genetic code, thereby producing the anomaly of development.

Primary infection in the mother's body and the pathological processes associated with it, reflect the level of immunity the pregnant woman, and the virulence of CMV. With the defeat of cytomegalovirus fetus baby may be born with multiple congenital malformations or antenatal death of the fetus.

When infected in the later stages may be congenital cytomegaly, which is manifested by lesions of the Central nervous system, organs of sight and hearing.

Localization in the body

The source of infection supports the patient in an acute or latent form of infectious diseases – often with latent persistence of the virus. Detection of DNA of the virus is possible after 4-6 weeks from initial infection. Invasion of the body can last from several months to several years.

Favourite localization of the virus in a human patient is in the respiratory system, glands of internal and mixed secretion, digestive and Central nervous system.

Steady immunity to cytomegalovirus is not produced, despite the susceptibility of the human body. And the high content of IgG antibodies does not speak about the impossibility of infection with cytomegalovirus.

DNA detection of cytomegalovirus

To determine the presence of CMV just because it belongs to the family of herpes viruses, but it stands out in the group of TORCH-infections.

Enzyme-linked immunosorbent assay used in the differential diagnosis from such diseases as infectious mononucleosis, the Epstein-Barr. But more informative method – polymerase chain reaction (PCR), allow maximum accuracy to detect the DNA fragments of CMV. The probability of error, despite the uncertainty and the human factor tends to zero.

Mostdemonstration tests for CMV:

  • the method of fluorescent antibodies;
  • cytological examination;
  • the reaction of binding complement;
  • settimanalmente antigen detection;
  • study specific entiteld and IgG;
  • molecular biological diagnostic methods for viral infections (PCR).

Prevention and treatment

Must be tested for the presence of cytomegalovirus infection at the slightest suspicion, especially perforadas women, as well as timely treatment or translation of the disease is in remission significantly increases the possibility of having a healthy child.

In modern medicine there are a large number of drugs for the treatment of CMV, however, before taking consult with your doctor.