To determine levels of direct and indirect bilirubin in hepatitis
What is the bilirubin?
Bilirubin is a specific enzyme having a greenish-yellow color. This substance is formed from hemoglobin as a result of destruction of erythrocyte cells in the liver, spleen or bone marrow. Increased content of the enzyme in the blood indicate the presence of pathologies of the liver or hematopoietic system.
There are several reasons that can cause an increase in bilirubin. These include the following factors:
- Violation of the secretion of bile into the intestinal cavity.
- Elevated concentrations of erythrocyte cells in the blood.
- Pathological disturbances of the functioning of the hepatic secretion.
- Of liver damage.
- Violation of the integrity of biological chain, ensuring the processes of biosynthesis.
- Hepatic lesions, with the attendant violation of the processes of binding of bilirubin.
- Accelerated destruction of erythrocyte cells (in the process of hemolysis).
Transcript of analysis results
To conduct the study on bilirubin uses blood taken from the cubital vein of the patient. Through laboratory biochemical analysis specialist receives information about the concentration of total, direct and indirect bilirubin in the blood. Further interpretation of data on the content of all three enzyme forms are compared with existing norms of indicators for each of them.
What is the bilirubin in the blood can be considered normal? We emphasize that while the interpretation of the results of the analysis takes into account factors such as the patient's age and gender. For example, the concentration of enzyme in the blood of women always lower than men. The reason for this is lower production of red blood cells in the female body.
The norm with moms-to-slightly above average. Very often the increase of concentration is observed during the third trimester of pregnancy.
The average normal level of total bilirubin in the blood is between 3.4 to 17.2 µmol/L. as for direct bilirubin, it is normal content should range from 0-3,5 umol/L. the Normal indirect bilirubin is 12 µmol/l and below.
All exceeding the normal content of bilirubin in the blood is considered to be a clear sign of liver damage with hepatitis.
In the case of mildhepatitis indicators should be no more than 85 µmol/L. hepatitis of moderate severity - from 87 to 159 µmol/L. In the case of diagnosing hepatitis severe levels of bilirubin are able to exceed 160 mmol/L.
Analysis of bilirubin is an important diagnostic procedure that allows to determine the incidence of hepatitis in the early stages of its development and to assign optimal, timely treatment.